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Successful Treatment of Patients With Multiple Myeloma and Impaired Renal Function With Lenalidomide: Results of 4 German Centers
20 February 2012
Katharina Oehrlein, Christian Langer, Isrid Sturm, Wolfram Pönisch, Corinna Hahn-Ast, Sigrid Kuhn, Katja C. Weisel
Micro-Abstract: Retrospective multicenter analysis of 26 patients with multiple myeloma to assess the efficacy and toxicity of relapse treatment with lenalidomide/dexamethasone in renal-function impai...
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Ten-Year Relative Survival and Causes of Death in Elderly Patients Treated With R-CHOP or CHOP in the GELA LNH-985 Trial
02 February 2012
Nicolas Mounier, Natacha Heutte, Catherine Thieblemont, Josette Briere, Philippe Gaulard, Pierre Feugier, Hervé Ghesquieres, Eric Van Den Neste, Daniela Robu, Herve Tilly, Reda Bouabdallah, Violaine Safar, Bertrand Coiffier, Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Advances in lymphoma therapy have resulted in improved cure rates and an increasing number of long-term survivors. The addition of rituximab (R) to the standard treatment regimen composed of cyclophos...
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TGF- β1–mediated Apoptosis Associated With SMAD-dependent MitochondrialBcl-2 Expression
02 February 2012
Masoomeh Bakhshayesh, Farhad Zaker, Mehrdad Hashemi, Majid Katebi, Mansooreh Solaimani
Micro-Abstract: Transforming growth factor β1 can elicit various cellular responses. The present study was characterized in 2 B-lymphoma cell lines, Burkitt and pre–B cell, which focused on the role o...
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Phosphorylated AKT Protein Is Overexpressed in Human Peripheral T-cell Lymphomas and Predicts Decreased Patient Survival
02 February 2012
Qingqing Cai, Haixia Deng, Dan Xie, Tianxin Lin, Tongyu Lin
Micro-Abstract: The expression of phosphorylated AKT (pAKT) in peripheral T-cell lymphomas (PTCL) and its clinical significance were studied. We detected pAKT expression by using the immunohistochemic...
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Molecular Resistance: An Early Indicator for Treatment Change?
30 January 2012
Carmen Fava, Hagop Kantarjian, Jorge Cortes
Abstract: Vigilant monitoring of a patient's response to current treatment is imperative to the management of chronic myeloid leukemia (CML). Early identification of treatment failure may increase the...
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