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Changes Associated With Lenalidomide Treatment in the Gene Expression Profiles of Patients With Del(5q)
21 May 2012
Monika Belickova, Jaroslav Cermak, Michaela Dostalova Merkerova, Jitka Vesela, Zdenek Krejcik, Eliska Cechova, Zuzana Zemanova, Kyra Michalova, Hana Votavova, Miroslav Caniga, Radana Neuwirtova, Anna Jonasova
Micro-Abstract: We used microarray profiling to investigate the direct effects of lenalidomide on gene expression in isolated CD14+ monocytes from 6 patients with del(5q). Our data demonstrate that ch...
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Clinical Cytogenetics in Pediatric Acute Leukemia: An Update
21 May 2012
Maria Braoudaki, Fotini Tzortzatou-Stathopoulou
Abstract: Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prog...
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A Phase II Study of Lenalidomide Alone in Relapsed/Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes With Chromosome 5 Abnormalities
14 May 2012
Yiming Chen, Hagop Kantarjian, Zeev Estrov, Stefan Faderl, Farhad Ravandi, Kristy Rey, Jorge Cortes, Gautam Borthakur
Micro-Abstract: This phase II study assessed the efficacy and safety of lenalidomide in patients with relapsed/refractory acute myeloid leukemia (N = 18) and high-risk myelodysplastic syndrome (N = 9)...
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Mutational Status and Gene Repertoire of IGHV-IGHD-IGHJ Rearrangements in Serbian Patients With Chronic Lymphocytic Leukemia
07 May 2012
Teodora Karan-Djurasevic, Vuk Palibrk, Tatjana Kostic, Vesna Spasovski, Gordana Nikcevic, Sanja Srzentic, Milica Colovic, Natasa Colovic, Ana Vidovic, Darko Antic, Biljana Mihaljevic, Sonja Pavlovic, Natasa Tosic
Micro-Abstract: The mutational status and configuration of immunoglobulin heavy variable (IGHV) gene rearrangements was analyzed in 85 Serbian patients with chronic lymphocytic leukemia (CLL). We foun...
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Clinical Binding Properties, Internalization Kinetics, and Clinicopathologic Activity of Brentuximab Vedotin: An Antibody-Drug Conjugate for CD30-Positive Lymphoid Neoplasms
27 April 2012
Jonathan R. Fromm, Julie A. McEarchern, Dana Kennedy, Anju Thomas, Andrei R. Shustov, Ajay K. Gopal
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